"Sick with grief" describes the profound toll of loss on our bodies during the grieving process. Grief is defined as the deep emotional response to loss, and encompasses a spectrum of reactions that extend beyond mere mourning. Alongside its emotional weight, grief also manifests physically, with symptoms such as headaches, fatigue, changes in appetite and sleep patterns, and a weakened immune response. Exploring the physical domain of grief, Kirtly Jones, MD, discusses the interconnection between emotional and physical well-being during times of loss.