As a society, we have seen many health crises—smallpox, measles, polio, influenza, and most recently, COVID-19. With viruses and diseases also come vaccinations. But with how much we know, there is still so much we do not know about our immune system. How do vaccines work to protect us against viruses? Where do viruses come from in the first place? Can vaccines weaken our immune system? It is hard to get rid of bad information when you do not have the knowledge needed to make the best decision. Kirtly Jones, MD, discusses the risk-benefit ratio of vaccines as she explores the history of vaccination.