University of Utah researchers have discovered a genetic variation in mice that predisposes them toward developing severe, inflammatory arthritis. The finding implicates a new class of genes in arthritis progression, potentially opening doors to new treatment options for sufferers of rheumatoid arthritis and Lyme arthritis. Dr. Janis Weis, professor of pathology, and Dr. Kenneth Bramwell, postdoctoral fellow in pathology, discuss what they found and where their work might lead.