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Genome sequencing - reading our complete set of DNA instructions - is a powerful tool for understanding and diagnosing disease, and has become integral to precision medicine, a movement to bring the right treatment to the right person and the right time. Does that mean that everyone should have their DNA sequenced? Eric Green, MD, PhD, director of the National Human Genome Research Institute, discusses this and other questions brought forth by the rapid rise of genomic technologies with Lynn Jorde, PhD, chairman of the department of human genetics at the University of Utah and executive director of the Utah Genome Project.